Bluesky's Top 10 Trending Words from the Past 10 Minutes: ️⚠️💨18 - ventottenhambrennanunitedmickyanilpinmanchesterspurshag呪術 (tap/click to see all posts on Bluesky featuring that word!) #йобанарусня 🇺🇦

Amazing news! Vaccines work - no cases of cervical cancer detected in Scottish cohort #immunoskywww.statnews.com/2024/01/25/h...

There is something #motherly#SciArtSeptember#SciArt#immunoSky 🧪

'Of note, PD-L1 expression did not positively correlate with TMB in any of these studies, indicating that the two biomarkers are largely independent both in patients with NSCLC and with other cancers' #Immunology#Immunotherapy#Immunoskywww.nature.com/articles/s41...

Tumour mutational burden: clinical utility, challenges and emerging improvements - Nature Reviews Clinical Oncology

Tumour mutational burden (TMB), reflecting the number of mutations present in the DNA of a tumour, is a biologically appealing biomarker of a response to immune-checkpoint inhibitors (ICIs). Nonethele...

'In vertebrates, some astrocytes may even be involved in the presentation of antigens to infiltrating T cells. This places them as key initiators of the earliest response to inflammation, without the need for a myeloid cell intermediary.' #Immunology#Immunoskywww.cell.com/trends/immun...

Emerging roles of astrocytes as immune effectors in the central nervous system

The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocyte...

'Human IgA consists of two subclasses—IgA1, which makes up the bulk of circulating IgA, and IgA2, which, along with IgA1 is present at substantial levels in mucosal sites. In contrast, mice have just one IgA subclass, an important distinction for experimental interpretation' #Immunology#Immunosky

All roads lead to IgA: Mapping the many pathways of IgA induction in the gut

The increasing prevalence of food allergy and related pathologies in recent years has underscored the need to understand the factors affecting adverse reactions to food. Food allergy is caused when f....

#MedSky🧪#iDSky#ImmunoSky#COVID#SARSCoV2www.sciencedirect.com/science/arti...

Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants

Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection. Despite widespread vaccination, some HCWs develop frequent symptomatic infect…

#MedSky🧪#IDSky#ImmunoSky the regulatory effect of FASN( fatty acid synthase ) on immune cells, and the progress in research & the implications of FASN in immune-related diseases.

#MedSky🧪#IDSky#ImmunoSky#Gutbrainaxiswww.sciencedirect.com/science/arti...

The role of Kupffer cells in microbiota-brain communication: Sleep and fever signaling in response to lipopolysaccharide

Microbial molecules translocated from the intestinal lumen into the host’s internal environment play a role in various physiological functions. Previo…

#MedSky🧪#IDSky#Biology#ImmunoSky#SARSCoV2#COVID19 reported recently

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

Interferons (IFNs) have a role in the regulation of virus-host interactions. This study uses genome-wide CRISPR knockout screen data to identify 28 genes that impact SARS-CoV-2 infection, including PL...