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Rrevan.social

Semaglutide specifically has been approved for 7 years. The older GLP-1 agonists have been approved for up to two decades though.

• exenatide (brand names Byetta and Bydureon, manufactured by AstraZeneca), approved in 2005/2012
• liraglutide (Victoza for diabetes, Saxenda for obesity, manufactured by Novo Nordisk), approved in 201035]
• albiglutide (Tanzeum, manufactured by GSK), approved in 2014[36]
• dulaglutide (Trulicity, manufactured by Eli Lilly.), approved in 2014[37]
• lixisenatide (Lyxumia in Europe, Adlyxin in the United States, manufactured by Sanofi), approved in 2016[381
• semaglutide (Ozempic and Rybelsus for diabetes, Wegovy for obesity, manufactured by Novo Nordisk), approved in 2017|391
• tirzepatide (dual GLP-1 and GIP agonist;
Mounjaro for diabetes, Zepbound for obesity, manufactured by Eli Lilly), approved in 2022|40]
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Mmalraux.bsky.social

One last thing is that liraglutide (victosa) is going to generic this year. It’s not quite as effective as semaglutide in trials, but still a generic version will help with production bottle necks, give some options, etc.

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cnm.bsky.social

There is quite a substantial history of use of GLP-1 Agonists, Liraglutide and Dulaglutide before Semaglutide. The side effect profile is quite well known and they are safe and effective. This isn't Phen-fen.

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RCrche54.bsky.social

Fun fact, there was actually a GLP1 analogue used to treat diabetes before liraglutide--it was called Exenatide and it came from a toxin found in the saliva of the gila monster! www.nhm.ac.uk/discover/the...

Gila monster: meet the reptile whose bite is saving lives
Gila monster: meet the reptile whose bite is saving lives

The Gila monster's bite is agonising, but humans have been using this lizard's venom to save lives.

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ISihaque.bsky.social

Interesting article on the invention of liraglutide, but biggest 🤯 for me - laundry detergent works by... dissolving the cotton?! Effective, sure, but... pubs.acs.org/doi/full/10....

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Pkutheks.bsky.social

big pharma heeft nog nooit een studie betaald die aan moet tonen dat medicijnen veilig zijn voor transen simpelweg omdat transen een te kleine doelgroep zijn om bijzonder winstgevend te zijn. deze studie is wel betaald door big pharma

How well the drug works

The trial included 82 children with an average BMI of 31 who either got a once-daily injection of liraglutide or a placebo for 56 weeks. 

Every child and their parents in the study also met regularly with a lifestyle coach to discuss healthy eating and exercise before starting the injections, said lead study author Dr. Claudia Fox, an associate professor of pediatrics at the University of Minnesota. Fox serves as a principal investigator for clinical trials sponsored by both Novo Nordisk and Eli Lilly.
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