bio.nikkeibp.co.jp/atcl/news/p1... 安全性の高いAAVベクター(アデノウイルス)を血中に入れ、異物を駆除するT細胞遺伝子を発現させて治療するとかその臨床試験をアメリカが始めたと書かれている記事。 現在シスプラチン(プラチナ系)のものやリツキシマブ(人･マウスキメラモノクローナル抗体)とか抗がん剤にアレルギー反応がある方の希望となるのではないか。 ずいぶん前から力を注いでいる武田薬品さん頑張って欲しいなぁ。
AAVベクターを用いて体内でT細胞エンゲージャーを血中に発現させるがん遺伝子治療を開発している米Vironexis Biotherapeutics社は、2024年9月12日、ステルス状態を脱した。同社は、「TransJoin」 AAV遺伝子治療プラットフォームの概要と、これを用いて構築した10を超える製品候補のパイプラインのなかのVNX-101が、米国で臨床試験開始許可を獲得したことを明らかにした...
An all-in-one AAV vector for cardiac-specific gene silencing by an adenine base editor www.biorxiv.org/content/10.1101/2024.09.30.615742v1
ABE editing outcomes are highly variable and unpredictable, depending on various factors. Therefore,
An all-in-one AAV vector for cardiac-specific gene silencing by an adenine base editor www.biorxiv.org/content/10.1101/2024.09.30.615742v1
ABE editing outcomes are highly variable and unpredictable, depending on various factors. Therefore,
Does anyone have recommendations RE: serotype (or anything else) for expressing two AAV viruses in the same neuron eg selective promotor-cre and cre dependent virus? Use the same serotype? Recs on Serotypes that behave well together? Inject at the same time or in different surgeries?
Super useful AAV enhancers from @alleninstitute.bsky.social to target striatal cell types!
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits https://www.biorxiv.org/content/10.1101/2024.09.27.615553v1
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Be
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits www.biorxiv.org/content/10.1101/2024.09.27.615553v1
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Be
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits www.biorxiv.org/content/10.1101/2024.09.27.615553v1
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Be
sensory neuron biology, and modeling disease. To date, there is no consensus on the optimal AAV serotype for efficient and selective transduction of olfactory sensory neurons in vivo….
Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons www.biorxiv.org/content/10.1101/2024.09.26.615247v1
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor inform
Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons www.biorxiv.org/content/10.1101/2024.09.26.615247v1
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor inform