Impact of Guanidine Hydrochloride on the shapes of Prothymosin-α and α-Synuclein is dramatically different www.biorxiv.org/content/10.1101/2024.10.01.616064v1
The effects of Guanidine Hydrochloride (GdmCl) on two Intrinsically Disordered Proteins (IDPs) are i
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and combines a direct antiviral effect with subtle boosting of interferon www.biorxiv.org/content/10.1101/2024.09.09.611961v1
The approval of COVID-19 vaccines and two classes of antiviral drugs has been crucial in addressing
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and combines a direct antiviral effect with subtle boosting of interferon www.biorxiv.org/content/10.1101/2024.09.09.611961v1
The approval of COVID-19 vaccines and two classes of antiviral drugs has been crucial in addressing
Growth of complete ammonia oxidizers on guanidine www.nature.com/articles/s41...#jcampubs
Nitrospira inopinata and probably most other comammox microorganisms can grow on the non-conventional substrate guanidine as the sole source of energy, reductant and nitrogen.
We will also investigate whether adding guanidine to agricultural fertilizers increases the abundance of comammox bacteria in arable soils, thereby reducing agricultural nitrous oxide emissions as comammox nitrifiers low amounts of this greenhouse gas www.nature.com/articles/s41...
We are now attempting to isolate comammox bacteria from environmental samples using guanidine, as only one strain is currently available in pure culture. This seems particularly promising as none of the other nitrifier strains we tested could grow with guanidine.
Functionally redundant microbes can coexist by partitioning low-concentration substrates even though they compete for one dominant substrate. Thus, the ability to use the low-concentration substrate guanidine provides an additional niche for comammox
Furthermore, we detected guanidine in faecal samples from cows, pigs, chicken and sheep and demonstrated guanidine degradation by ammonia-oxidizers in a comammox containing agricultural soil.
As guanidine has been detected in human urine at concentrations between 2 and 20 μM we hypothesized that comammox microorganisms in wastewater treatment plants degrade guanidine under competitive conditions and demonstrated this experimentally.
