Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability www.biorxiv.org/content/10.1101/2024.09.07.609774v1
Alcohol use disorder (AUD) is characterized by compulsive alcohol consumption and negative emotional
Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability www.biorxiv.org/content/10.1101/2024.09.07.609774v1
Alcohol use disorder (AUD) is characterized by compulsive alcohol consumption and negative emotional
Study reveals key brain cells help resist food temptations in favor of exercise 🧠🏃🍓 www.news-medical.net/news/2024080...#Neuroscience#Obesity#Exercise#Orexin#Hypocretin#BrainHealth#TemptationResistance#HealthyLiving#PhysicalActivity#Research@natureportfolio.bsky.social
Hypocretin/orexin neurons (HONs) are crucial for resisting temptation and choosing exercise over highly palatable foods. This finding highlights potential targets for promoting physical activity and c...
The average length of time between onset of symptoms and diagnosis of Narcolepsy is between 8 and 22 YEARS. Plus, Narcolepsy with Cataplexy is an autoimmune disease, wherein the body attacks the nerve cells that receive hypocretin, which regulates sleep.
mouse model: suvorexant reduces addictive potential of opioids by preventing increased projections of hypocretin neurons into pleasure-related brain regions
The authors demonstrate that, in a mouse model of heroin use disorder, co-administration of morphine and suvorexant prevented both morphine-induced anatomical changes in hypocretin neurons and morphin...
The good news is that part of my brain might not be destroyed, only damaged. There is some evidence an epigenetic therapy might bring hypocretin production back in my brain! 7/7 pubmed.ncbi.nlm.nih.gov/37126681/
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-p...
The greatest anxiety for me right now is knowing how #narcolepsy#LongInfluenza#LongCOVID means for me. 6/🧵
Encephalon 12: Medial Temporal Lobe and Hypocretin in Memory and Navigation “… Understanding these mechanisms provides valuable insights into the neural basis of memory and could inform the development of therapeutic strategies for memory disorders…” mustafakorkutata.medium.com/encephalon-1...
Memory is a complex cognitive process that involves encoding, storing, and recalling information. One of the critical regions in the brain…
If adenosine inhibits activity of hypocretin/orexin neurons, so sleep-promoting effect, yet caffeine is known to block adenosine receptors, my hunch is that it might be something to do with a re-uptake mechanism / metabolism, meaning there is excess now blocked from re-uptake, hence insta max sleepy
A direct estrogenic involvement in the expression of human hypocretin www.biorxiv.org/content/10.1101/2023.12.21.572761v1
Background: Hypocretin-1 may play an important role in depression, which was increased in female dep