#Inflammasomewww.nature.com/articles/s41...
Inflammasomes are signalling machines that drive inflammation. This Review highlights the signalling biology of inflammasomes and how we can use small molecules or biologics to block pathological infl...
and Pyrin canonical caspase-1-containing inflammasomes, and the caspase-11 non-canonical inflammasome. These inflammasome sensors can sense PAMPs from bacteria, viruses and protozoa, or DAMPs in the form of mitochondrial damage, ROS, stress and heme.
These inflammasome sensors can sense PAMPs from bacteria, viruses and protozoa, or DAMPs in the form of mitochondrial damage, ROS, stress and heme. The best-characterized inflammasome complexes are the NLRP3, NAIP-NLRC4, NLRP1, AIM2,
driving the secretion of the pro-inflammatory cytokines IL-1β and IL-18 & pyroptosis. This #Clinicalreview on the Molecular mechanisms of emerging inflammasome complexes & their activation signaling in inflammation & pyroptosis
Passenger mutations in KO mice can influence gene expression & impact experimental results. 3 studies this month highlight this issue - Ackr1 & Ackr2 (chemokine) doi.org/10.1093/jleu...doi.org/10.1093/jleu...doi.org/10.1038/s414... Always consider them in your study design
Ackr1 knock-out mice carry a 6Mb fragment of the 129 strain genome on chromosome 1 near the Ackr1 locus, which alters the expression of immune genes, raisi
Global #GasderminD/GSDMD#ThoracicAorticDissecition#IntramuralHematoma#Pyropotosis#Inflammasomewww.biorxiv.org/content/10.1...
Cerebroprotection by dioscin after experimental subarachnoid hemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway Br J Pharmacol - Zhang, 2021 Temp link here: sci-hub.se/10.1111/bph.15507
Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center www.biorxiv.org/content/10.1101/2024.09.12.612739v1
The NLRP3 inflammasome is a multi-protein molecular machine that mediates inflammatory responses in