For certain monosaccharides, we could not identify/predict transporter genes, and that led to false negative predictions. This observation points to the existence of some yet uncharacterized monosaccharide uptake mechanisms in bifidobacteria (13/)
Bifidobacteria are saccharolytic microbes, and the carbohydrate composition of the diet is one of the primary factors dictating their colonization efficiency. For example, glycans found in human milk are known to promote the growth of particular species during infancy (2/)
Happy to share a preprint with the results of my PhD work on creating a comprehensive genomic encyclopedia of carbohydrate metabolism in human-colonizing bifidobacteria. TL;DR: there's tons of variability. A thread with results (1/) www.biorxiv.org/content/10.1...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Integrative genomic reconstruction of carbohydrate utilization networks in bifidobacteria: global trends, local variability, and dietary adaptation www.biorxiv.org/content/10.1101/2024.07.06.602360v1
Bifidobacteria are among the earliest colonizers of the human gut, conferring numerous health benefi
Integrative genomic reconstruction of carbohydrate utilization networks in bifidobacteria: global trends, local variability, and dietary adaptation www.biorxiv.org/content/10.1101/2024.07.06.602360v1
Bifidobacteria are among the earliest colonizers of the human gut, conferring numerous health benefi
Both rheumatoid arthritis and multiple sclerosis have been observed to be impacted by gut bacteria pretty significantly. Shifts during pregnancy to support lactobacillus and bifidobacteria could be upstream of temporary disease remission.
We found extensive carriage of antimicrobial resistance genes (ARGs) in breastmilk, as well as in the infant gut, and that samples dominated by bifidobacteria were characterised by a significantly lower carriage of ARGs. 7/n
The prevalence of bifidobacteria decreased over time, particularly in infants that switched to formula feeding. In addition, samples dominated by B. longum showed a higher stability over time, compared to samples dominated by other species. 5/n
