Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia www.nature.com/articles/s41...

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia - Nature Genetics

Analysis of exomes and transcriptomes from 100 African American patients with acute myeloid leukemia identifies ancestry-related variation in mutation profiles and survival. Refined risk classificatio...

📃Scientific paper: Differential effects of poly(ADP ribose) polymerase inhibitor-based metronomic therapy on programmed death-ligand 1 and matrix-associated factors in human myeloid cells ➡️ Continued on ES/IODE

Very cool new paper suggesting that #helminths#inflammation#neuron#myeloid#IL-33#ImmunoSkywww.nature.com/articles/s41...

MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33 - Nature Immunology

Herbert and colleagues show MrgprA3+ neurons activate myeloid cells to promote cutaneous IL-17-dependent immunity against Schistosoma mansoni.

Dual Specificity Phosphatase 3 knockdown drives myeloid leukemia cells to differentiate into macrophages and polarize www.biorxiv.org/content/10.1101/2024.09.30.615030v1

Dual Specificity Phosphatase 3 knockdown drives myeloid leukemia cells to differentiate into macrophages and polarize https://www.biorxiv.org/content/10.1101/2024.09.30.615030v1

The dual-specificity phosphatase 3 (DUSP3) has been implicated in the maintenance of genomic stabili

Authors demonstrated that: 1) PHF6 maintains AML via regulating NF-κB signaling pathway 2) a treatment of PHF6 over-expressed myeloid leukemia cells with a NF-κB inhibitor significantly increased tumor cell apoptosis and decreased their proliferation. mappingignorance.org/2024/07/29/p...

The role of PHF6 in acute myeloid leukemia

Plant homeodomain finger gene 6 is a highly conserved epigenetic transcriptional regulator that plays critical roles in myeloid leukemia

Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model www.biorxiv.org/content/10.1101/2024.09.27.615313v1

Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model https://www.biorxiv.org/content/10.1101/2024.09.27.615313v1

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Internal tandem du

Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model www.biorxiv.org/content/10.1101/2024.09.27.615313v1

Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model https://www.biorxiv.org/content/10.1101/2024.09.27.615313v1

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Internal tandem du

'In vertebrates, some astrocytes may even be involved in the presentation of antigens to infiltrating T cells. This places them as key initiators of the earliest response to inflammation, without the need for a myeloid cell intermediary.' #Immunology#Immunoskywww.cell.com/trends/immun...

Emerging roles of astrocytes as immune effectors in the central nervous system

The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocyte...

Replication of a GWAS signal near HLA-DQA2 with acute myeloid leukemia using a disease-only cohort and external population-based controls www.medrxiv.org/content/10.1101/2024.09.26.24314422v1

Replication of a GWAS signal near HLA-DQA2 with acute myeloid leukemia using a disease-only cohort and external population-based controls https://www.medrxiv.org/content/10.1101/2024.09.26.24314422v1

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Its risk factors i

#MedSky🧪#IDSky#Immunoskyrupress.org/jem/article/...