Very happy about the first preprint of my work with @oconnorlab.bsky.social#natprod#PlantBiologywww.biorxiv.org/content/10.1...

Independent evolution of ipecac alkaloid biosynthesis

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice www.biorxiv.org/content/10.1... "Laboratory Grown Mouse strains of these ancestral symbionts have experienced accelerated accumulation of genetic load during the past ∼ 120 years of captivity"

Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice

Laboratory mice ( Mus musculus domesticus ) harbor gut bacterial strains that are distinct from those of wild mice[1][1] but whose evolutionary histories are poorly understood. Understanding the diver...

Strainy: phasing and assembly of strain haplotypes from long-read metagenome sequencing www.nature.com/articles/s41...github.com/katerinakaza...

Strainy: phasing and assembly of strain haplotypes from long-read metagenome sequencing - Nature Methods

This work presents Strainy, a long-read metagenome assembler that allows the identification of strain distributions and mutational patterns in environmental metagenomes.

Adaptation to high pressure; insights from the genome of an evolved Escherichia coli strain with increased piezotolerance www.biorxiv.org/content/10.1...#jcampubs

A host-adapted auxotrophic gut symbiont (Tomasiella immunophila) induces mucosal immunodeficiency (in mice) www.science.org/doi/10.1126/...

A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency

Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We sh...

Thread. Science can be better, but often institutions respond to risk with expensive and even harmful bureaucratic theater (think post-9/11 airport security). We want rigor in science, but I don't believe this can be achieved with prescriptive rules derived from one field's methodological crisis.

CTcarlbergstrom.comSep 26, 2024 5:52am

This week, the touchstone paper purporting to show that there are replicability benefits of preregistration was retracted. For me this highlights a long-running disagreement I've had with core CoS strategy. I like the idea of making things possible, easy, and rewarding.

Of course they do…cool!

CTjcamthrash.bsky.socialSep 26, 2024 1:30pm

Intragenic DNA inversions expand bacterial coding capacity www.nature.com/articles/s41... #jcampubs

Intragenic DNA inversions expand bacterial coding capacity - Nature

Reversible DNA inversions found entirely within genes enable increased coding capacity by encoding multiple versions of a protein in bacteria and archaea.

This is a very good piece, and ties together a number of cultural trends that make this a Golden Age for lying wellness grifters:

AMamandamarcotte.bsky.socialSep 26, 2024 10:38am

There's "a shared reliance on a fantasy of a glorious past that is allegedly being stolen from us by modern progress. In both tellings, the past was better — utopian, even — because people stuck to the 'natural' order." www.salon.com/2024/09/26/r...

RFK Jr. and Jordan Peterson's D.C. roundtable shows why "alternative medicine" went full MAGA

Despite a crunchy exterior, "alternative medicine" has always been rooted in opposition to social progress

Question for you on this, in general would you think B. subtilis is more easily isolated from the rhizosphere or from bulk soil like this work?

watch A. borkumensis "at work", that is eating up oil droplets. #MicroSkywww.science.org/doi/10.1126/...

Alcanivorax borkumensis biofilms enhance oil degradation by interfacial tubulation

A type of oil-eating bacteria adapts its biofilm interfacial properties to accelerate the rate of oil consumption.