Check out our recent preprint, co-led by two former PhD students in the lab Daniela Soto and José Uribe-Salazar, in which we identify and characterize human duplicated genes implicated in brain evolution. www.biorxiv.org/content/10.1...
Genomic drivers of human-specific neurological traits remain largely undiscovered. Duplicated genes expanded uniquely in the human lineage likely contributed to brain evolution, including the increase...
Busy week! See also "Gene expansions contributing to human brain evolution" from T2T members Daniela Soto and Megan Dennis utilizing the T2T-CHM13 reference assembly www.biorxiv.org/content/10.1...
Genomic drivers of human-specific neurological traits remain largely undiscovered. Duplicated genes expanded uniquely in the human lineage likely contributed to brain evolution, including the increase...
The era of "whole genome sequencing" is finally here 😉
Another great Verkko-enabled preprint out this week "Complex genetic variation in nearly complete human genomes" from the Human Genome Structural Variation Consortium, including variant analysis of 65 near-T2T diploid human genomes: www.biorxiv.org/content/10.1...
Diverse sets of complete human genomes are required to construct a pangenome reference and to understand the extent of complex structural variation. Here, we sequence 65 diverse human genomes and buil...
T2T assemblies from none other than @sergek.bsky.social wielding Verkko 🪡
Such an enjoyable collaboration with Jen Gerton, @erikg.bsky.social@leogdlima.bsky.social@andreaguarracino.bsky.social and co. I've learned so much and had so much fun working this group! Much more acrocentric goodness still to come from this team 😄
"The formation and propagation of human Robertsonian chromosomes" ROBs are the most common translocation in humans, approx. ~1 per 800 people. Last year we proposed a simple mechanism for ROB formation; This year we prove it by finishing some T2T! New preprint: www.biorxiv.org/content/10.1...
🗞 The ERGA Assembly Report (EAR) ensures high-quality genome assemblies across diverse projects by using the Galaxy platform! Key features include: -Read QC -Assembly & gene completeness -Contaminant screening -Detailed documentation Learn more: galaxyproject.org/news/2024-09...
Discover more about the ERGA Assembly Report – a comprehensive, community-driven Genome assembly Quality Control Document.
If you're interested in a PhD applying stat/AI methods to prediction of phage susceptibility & cocktail design with me, @edzewestra + @StinekevanHoute , we're advertising an MRC funded project - deadline 4th November. International students welcome! www.findaphd.com/phds/project...
PhD Project - GW4 BioMed2 MRC DTP PhD project: Using AI to understand defence and counter-defence systems between bacteria and phage at University of Bath, listed on FindAPhD.com
Nice! Some conclusions consistent with genomebiology.biomedcentral.com/articles/10.... 🙂
Background Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this variation impacts epigenetic states and expression of the ...