It’s possible. My dentist though will hit me several times, regardless. He says if the patient can feel it, the dentist didn’t do it right. But it is not unheard of to be resistant. www.bbc.com/future/artic...

The people who can’t go numb at the dentist’s

Some people are resistant to local anaesthetic, meaning they must endure dental and medical procedures without such pain relief. And we’re only beginning to understand why

Dude is good. My wife raves about him, the other procedures he did for me that didn’t require anesthesia were great. The shots went into my soul. There’s no chance all 3 “missed”.