There are no vaccines to prevent or medicines to treat Oropouche. The best way to protect yourself from Oropouche is to prevent bites from biting midges and mosquitoes in areas where the virus is known to occur: South America, Central America, & the Caribbean.

Use Environmental Protection Agency (EPA)-registered insect repellents. When used as directed, EPA-registered repellents are safe and effective, labeled for flies, biting flies, or Culicoides (biting midges, punkies, granny nippers, & no-see-ums). Prevent bites if going to area with Oropouche virus.