Also “Are there any pathogens that have ubiquitin inhibitors to evade Class I?” The students were really on fire today
Another question today (and yes I know the answer to this one but I was still impressed by the question): wait, so if a self-protein got an amino acid change from a mutation like what would happen in a cancer cell, would that now be presented and act as a foreign antigen?
Do any MHC Class II molecules with CLiP make it to the cell surface in a normal individuals? If so, are they recognized by T cells? Are there any microbes that have a CLiP mimic peptide to evade Class II presentation?
Some of today’s fantastic questions (admittedly all answerable by thinking about pathogens as containing many epitope peptides or by thinking of MHC molecules presented by a cell as a population but cool nonetheless…)
Today’s question: Do other animals have autoimmunity? What are some examples/what are they like? (My answer was yes but I didn’t know examples)
From earlier this semester: If someone has a severe bone break, will they have self reactive B cells leak out of the bone marrow before they can go through central tolerance, putting them at increased risk of autoimmunity?
Dear Mammoths: I feel you. Each spring, it feels like hay fever will wipe me out too.
Hay fever can ruin a summer’s day, but could it wipe out a species?
This looks like an awesome list and puts some great references on important topics all in one place. Excited to have found it