Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer www.biorxiv.org/content/10.1101/2024.09.26.615228v1
Proteins operate within dense interconnected networks, where interactions are necessary both for sta
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics www.biorxiv.org/content/10.1101/2024.09.26.615244v1
Temporal properties of molecules within signaling networks, such as sub-cellular changes in protein
Rapid prediction of thermodynamically destabilizing tyrosine phosphorylations in cancers www.biorxiv.org/content/10.1101/2024.09.26.614998v1
Tyrosine phosphorylations are a prominent characteristic of numerous cancers, necessitating the use
Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity www.biorxiv.org/content/10.1101/2024.09.25.615060v1
Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlockin
Heterogeneous Appetite Patterns in Depression: Computational Modeling of Nutritional Interoception, Reward Processing, and Decision-Making www.biorxiv.org/content/10.1101/2024.09.25.614954v1
Accurate interoceptive processing in decision-making is essential to maintain homeostasis and overal
An empirical model of aminoacylation kinetics for E. coli class I and II aminoacyl tRNA synthetases www.biorxiv.org/content/10.1101/2024.09.26.615143v1
Efficient functioning of the prokaryotic translational system depends on a steady supply of aminoacy
From tumor microenvironment to immuno-therapeutic outcomes for solid tumors: A systems theoretic approach www.biorxiv.org/content/10.1101/2024.09.26.615155v1
Increasing evidence suggests the tumor microenvironment (TME) governs solid tumor response to immune
Elucidating the role of multiple feedback loops in regulating stem cell decisions www.biorxiv.org/content/10.1101/2024.09.25.615049v1
Stem cell decisions are regulated by a complex network of gene regulatory pathways that determine th
Combined Stochastic Models for the Evaluation of Cancer Progression and Patient Trajectories www.biorxiv.org/content/10.1101/2024.09.26.615161v1
Cancer is a major burden of disease around the globe and one of the leading causes of premature deat
Unveiling allopolyploidization-driven genome duplications through progressive analysis of deep genome skimming data www.biorxiv.org/content/10.1101/2024.09.24.614835v1
Whole-genome duplication (WGD) events are widespread across the Web of Life (WoL). Given the prevale