Consoling: Chatting with AI can weaken beliefs in conspiracy narratives. Suspicion: AI may be capable of tricking us into any belief... www.science.org/doi/10.1126/...
Conspiracy theory beliefs are notoriously persistent. Influential hypotheses propose that they fulfill important psychological needs, thus resisting counterevidence. Yet previous failures in correctin...
MAGE-A3 degraders from the @craigmcrews.bsky.social lab. Nice example of how ligand discovery with DEL screening can mesh into degrader workflows.
Type I melanoma antigen (MAGE) family members are detected in numerous tumor types, and expression is correlated with poor prognosis, high tumor grade, and increased metastasis. Type I MAGE proteins a...
We definitely don’t know all the ins and outs of degrading proteins as a therapeutic mode. But every year more stuff gets clearer:
I’m growing tired of seeing “Hook effect” in the literature instead of “hook effect” — ffs people, it’s named after the shape of the dose-response curve, not everyone’s favorite pirate 🤦♂️
ALT: Hook Peterpan GIF
I spent my childhood in the GDR. I confirm this country was terrible. I remember the cognitive dissonance in school, avoiding classmates whose parents were probably Stasi informants, and mistrusting any authorities. I guess growing up in a dictatorship still has a profound impact on my personality.
Developing biologics that modulate LRRK2 features: # Cellular kinase activity # Filament formation # Overcome preferred orientation in cryo-EM @asapresearch.bsky.socialwww.jbc.org/article/S002...
New preprint available on Mechanism of human PINK1 activation at the TOM complex in a reconstituted system. Great collaboration featuring ASAP Project Manager, Sebastian Mathea and other researchers. Check it out! 🧪 www.biorxiv.org/content/10.1...
