Can't use two of the same character in this one. That's what's nicer about it, they all have more personality. For now my best run was with Hellion, Flagellant, Jester and Plague Doctor. They haven't released Abomination yet, but I think he's coming out in the next DLC <3

I do like the Flagellent, but I've had a bad experience with them. Your party heals when the Flagellant is at Deaths Door, thus maximizing survival chance at the Door increases utility. 90% resist to death, and the second attack during a boss causes him to tip over. I lost my backup crew.