This week, Jim Zhang (3rd year PhD student, @dukebrain.bsky.socialwww.science.org/doi/10.1126/...
Information stored in memory is selectively routed to the human frontal cortex only when a decision requires access to memory.
Thank you to the authors at Cedars Sinai for your work, and we look forward to following more of it! cc: Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam Mamelak, Ueli Rutishauser
[cont.] Could this signal be for general effort, instead of specifically for mnemonic information? Might the MFC send this same signal to synchronize with HA when it detects response conflict? Also why might theta be the frequency band at which this information transfer occurs?
❔3️⃣: How might the theta synchronization propagate from HA to MFC? Are there intermediate regions that may experience a spike in Average PPC first? What might the mechanism be through which MFC signals to HA that it requires theta synchronization to send mnemonic information?...
[cont.] could we expect an overlap in choice cells between the categorization task and a similarly effortful perceptual task?
❔2️⃣: Image categorization is a perceptual task and familiarity is a higher-level cognitive task. Controlling for effort, could we expect an overlap in choice cells between the familiarity task and a similarly effortful cognitive task? And similarly...
❔1️⃣: Supposing they had task switching within blocks, how might that affect the memory information? OR how might the memory information affect behavioral switch costs?
🤍3️⃣: Fig 5F is a beautiful and striking way to visualize different functional populations of cells. Overall, the visualizations throughout this paper were extremely clear and engaging, and are a wonderful model for how to communicate results.
🤍2️⃣: The control analyses that they did were brilliant. I especially appreciated Fig 4C, where they controlled for choice decoding potentially being caused by the ‘ground truth’.
🤍1️⃣: I loved that they had a summary page at the beginning of the paper, it made digesting the paper much easier.