This study was spearheaded by Sahil Batra, a postdoc in the Remus lab, and Benjamin Allwein, a graduate student of the BCMB PhD program at Weill Cornell Medicine/Sloan Kettering Institute in the Hite lab, with additional support from members of the Remus and Marians labs. 4/4
Unexpectedly, our analysis indicates that the CMG helicase translocates along DNA in a very different manner than previously thought: It moves like an inchworm rather than a rotary staircase. 3/4
We determined the structure of yeast and human CMG complexes stalled at a G-quadruplex (G4) in the leading strand template and found that the G4 is lodged fully folded inside the CMG central channel, stalling the CMG in the act of translocation. 2/4
Happy to announce a new preprint from our lab in collaboration with Richard Hite's lab at Sloan Kettering Institute: www.biorxiv.org/content/10.1... 1/4
DNA G-quadruplexes (G4s) are non-B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we have characterized ...
Cryo-EM structures of G4-stalled CMG reveal inchworm mechanism of DNA translocation www.biorxiv.org/content/10.1101/2024.10.02.616340v1
DNA G-quadruplexes (G4s) are non-B-form DNA secondary structures that threaten genome stability by i
New in Nat Comm: "We find 236,181 (~25%) human candidate cis-regulatory elements (cCREs) are TE-derived, with over 90% lineage-specific since the human-mouse split, accounting for 8–36% of lineage-specific cCREs." www.nature.com/articles/s41...
Half of our genome is transposable elements (TEs), often called junk DNA. Using the latest ENCODE data, the authors find TEs to contribute ~25% of human regulatory elements (REs). TEs can be adopted i...
Hi, I'm interested in contributing to the science feed with posts on genome integrity, biochemistry, structural biology scholar.google.com/citations?us...
Member, Memorial Sloan Kettering Cancer Center - Cited by 2,645 - DNA replication - chromatin - biochemistry
The Department of Biomolecular Chemistry at UW-Madison is hiring an Assistant Professor with a focus on gene expression, RNA biology, or cellular signaling. Join our collaborative and interdisciplinary department in beautiful Madison! Apply here: tinyurl.com/yc85hrcb
What happens when a replication fork encounters a cohesin complex? A new study #ScienceMagazinebit.ly/adf0224
Great collaboration with Boos lab finally out link.springer.com/article/10.1...