Reiji Ozora is a chronic quitter who never completes what's assigned or handed to him, but one day Maiko, his closest friend, walks him to a local arcade where the latest game craze is happening: Dragon Drive. After meeting Chibi, a seemingly meek dragon, Reiji wants to make himself and Chibi strong

Set in an alternate 19th century, the story focuses on an organization of exorcists, named the Black Order, as they defend humanity against the Noah Family, reincarnations of Noah and his twelve apostles whom bear hatred towards humanity and God led by a man known as the Millennium Earl.