I don’t think we’ve seen large scale (mass) use of GLP-1 drugs across enough populations and for long enough to make any bold assertions yet about their population-wide effects (I have 2 friends whose lives were totally transformed by these drugs, so clinically they can have big impact, for sure)

Yes, agreed-feels like we could do some quick back of the envelope on what is needed to move the needle at population level and my gut also says we wouldn't be there yet (but also hearing remarkable anecdotes from friends and family!).