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Graham Coop
@gcbias.bsky.social
Popgen @UCDavis @gcbias@ecoevo.social . Posts, grammar, & spelling are my views only. He/him. #OA popgen book github.com/cooplab/popgen-notes/releases
1.7k followers592 following367 posts
GCgcbias.bsky.social

An allele currently found only in European ancestry sequences will be present in India many times over for example. Rapid population growth means that there’s a vast reservoir of rare alleles within all human “ancestry groups". No rare allele will be specific to one of them. 3/n

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MWdrmikewiser.bsky.social

This assumes alleles as only a single base pair change, though, doesn't it? Alleles that are, say, 6 base pair changes off the line from the wild type allele could easily be specific to a particular group, I would think.

1
GCgcbias.bsky.social

It is true that if one focuses on a set of rare alleles descended from a particular mutation (identical by descent, IBD), which will reside on a specific long haplotype, that set will often be present in sequences restricted to particular genetic ancestries. 4/n

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GC
Graham Coop
@gcbias.bsky.social
Popgen @UCDavis @gcbias@ecoevo.social . Posts, grammar, & spelling are my views only. He/him. #OA popgen book github.com/cooplab/popgen-notes/releases
1.7k followers592 following367 posts