I love the concept of a Monster Hunter campaign. Go interesting places, hunt down cool dangerous monsters, harvest bits, turn bits into cool equipment/sell them. I ran it as a mini arc and included an airship-homebase system. It was a perfect combat heavy emergent gameplay sandbox engine

It is, for sure, a different angle than most ToX games. It'll involve pulling in some Cortex Prime mods that ToX doesn't use. Like Bosses. You can't have a monster hunter game without bosses. Also Scale. ToX challenges can handle these things, but it wouldn't be as fun.