How do karyotypes evolve? Turns out an intracellular tug of war within the metaphase spindle sets the limits for chromosome number evolution. Excited to see our study out today in Nature Cell Biology doi.org/10.1038/s41556-024-01485-w 1/9

Lovely work!!

This looks really cool!

Chromosome numbers can vary widely in nature, even between closely related species. Despite this, the mitotic machinery must accurately segregate each chromosome every cell cycle. We sought to understand the physical constraints dictating chromosome number evolution. 2/9