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Jeff Gilchrist
@jeffgilchrist.bsky.social
PhD Biomedical researcher, data scientist, and finder of large prime numbers. Views are my own. Twitter: @jeffgilchrist Mastadon: @jeffgilchrist@mstdn.science COVID-19 guides, stats, calculators & 600+ scientific articles: covid.gilchrist.ca
2k followers89 following891 posts
JGjeffgilchrist.bsky.social

That is page 1, just go to page 2 to see individual variants.

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JGjeffgilchrist.bsky.social

But neutralizing antibodies are just *one* part of the immune process so JN.1 vaccines will help other parts of the immune system protect you against more severe disease.

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JGjeffgilchrist.bsky.social

Unfortunately I'm not sure what is going on in the NZ area for vaccines and regulatory process. That being said, a JN.1 vaccine will produce an immune response but Dr. Cao roughly estimates a KP.2 vaccine formula might give a 2-3x higher neutralization level so more of a buffer room. 2/

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JGjeffgilchrist.bsky.social

We had to be somewhat vague in our post/document because things change all the time and as I found out afterwards, the EU is actually looking at new applications so they might be getting a KP.2 formula mRNA vaccine in the future while right now they have the JN.1 formula. 1/

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Reposted by Jeff Gilchrist
JGjeffgilchrist.bsky.social

Variants: JN.1 vs KP.2 vs KP.3.1.1 What do the variant designations like KP.3.1.1 mean and how does it compare to JN.1? How important is just 1 mutation? Can 1 mutation potentially affect our immunity and how vaccines are designed? Read on to find out more. 🧪🧵1/ #Variants#COVID#Immunity

Structural alignment of the AF2-predicted RBD conformational ensembles in the complexes with ACE2 for JN.1 (A), KP.2 (B) and KP.3 variants (C). Structural alignment of the AF2-predicted conformations with high pLDDT values > 80.0 and the cryo-EM structure of the BA.2.86 RBD-ACE2 complex (pdb id 8QSQ). The RBD conformations are shown in ribbons. The sites of unique BA.2.86 mutations D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q are shown in blue spheres on panels (A-C). Mutation L455S in JN.1 is shown in red spheres on panel A. The positions of KP.2 mutations R346T, L455S and F456L are shown in red spheres on panel B. The positions of KP.3 mutations L455S, F456L and Q493E are shown in red spheres on panel C. Image from: https://www.biorxiv.org/content/10.1101/2024.07.09.602810v1.full
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JGjeffgilchrist.bsky.social

Lots of whooping cough/pertussis going around as well. :-( I have heard from many families whose kids got COVID the first week back at school this year...

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JGjeffgilchrist.bsky.social

Yes I am here, just not on social media much these days except when I have a bit of free time to post some new things.

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JGjeffgilchrist.bsky.social

What variants are circulating now? - Canada - USA - United Kingdom - Europe - Asia - South America -Oceania 4/

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JGjeffgilchrist.bsky.social

Table of Contents ------------------- Variant Designations (e.g. KP.3.1.1) - Parent & Child Lineages - KP.3 vs KP.3.1 vs KP.3.1.1 - Variants that Start with X How does this relate to our immunity? How important is 1 mutation? 3/

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JG
Jeff Gilchrist
@jeffgilchrist.bsky.social
PhD Biomedical researcher, data scientist, and finder of large prime numbers. Views are my own. Twitter: @jeffgilchrist Mastadon: @jeffgilchrist@mstdn.science COVID-19 guides, stats, calculators & 600+ scientific articles: covid.gilchrist.ca
2k followers89 following891 posts