🎙️Podcast: Una revolución en cáncer de páncreas Los resultados de Fase 2 de Revolution Medicines con un inhibidor de KRAS abren una nueva etapa para una de las enfermedades más difíciles de tratar $RVMD Te lo contamos aquí 👇 open.spotify.com/episode/3r1x...

E03 - Revolution Medicines en Cáncer de Páncreas

Episode · PÍLDORAS de BIOTECH · Revolution Medicines ha enfrentado uno de los mayores desafíos de la oncología: KRAS, una diana terapéutica considerada como "undruggable" o imposible de atacar. En est...

#ESMO24 A summary of presentations that caught my eye: - STX-478 inhibitor in PIK3CA mutant tumors - BMS-986365 AR degrader/antagonist in mCRPC - BNT327 PD-L1/VEGF in EGFR-mutated NSCLC - NVL-655 inhibitor in ALK-mutated NSCLC - Ponsegromab anti-GDF15 for cancer patients with cachexia

Chemotherapy still preferred over Pluvicto in 2L mCRPC. Pluvicto is the SOC after chemo $NVS #ESMO24

Some competition for $RVMD at #ESMO24. Astellas' KRAS G12D degrader shows 33% ORR at the highest dose (n=12), with 42% in PDAC (n=7). Still low n, but as a reference $RVMD had a 27% ORR in Ras-mutant PDAC

Assembly theory is a method, not a theory. It is intriguing and may be very helpful to derive an explanation on the origin of life, but it's misnamed to make it seem like it explains something. It doesn't link.springer.com/article/10.1...

Assembly Theory: What It Does and What It Does Not Do - Journal of Molecular Evolution

A recent publication in Nature has generated much heated discussion about evolution, its tendency towards increasing diversity and complexity, and its potential status above and beyond the known laws ...

#BioSky

It would be nice to build a biotech community on this site. In three weeks I’ll be attending #ESMO24 and I’ll post some content here. Let’s see if we can bring some coverage of the conference here

How did life on Earth begin? Recent scientific advances suggest that all living beings are descended from a single gene that appeared around 4 billion years ago. New blog post Adam and Eve Existed: They Created the Genetic Code www.vineyardbooks.blog/p/adam-and-e...

Adam and Eve Existed: They Created the Genetic Code

How did life on Earth begin? Recent scientific advances suggest that all living forms are descended from a single gene that existed around 4 billion years ago. This gene encoded for two proteins that ...

Richard Dawkins’ “The Ancestor’s Tale” is orders of magnitude better than “The Selfish Gene”

“Despite his transcending influence, the life of the historical Jesus remains shrouded in mystery: was he driven by political motivations, as suggested by the designation “King”? What was the reason for his execution?” open.substack.com/pub/vineyard...

Who was Jesus really?

Christ and Barabbas: the two faces of Christianity's founding moment