Congrats to my UW colleague David Baker! www.nobelprize.org/prizes/chemi...
The Nobel Prize in Chemistry 2024 was divided, one half awarded to David Baker "for computational protein design", the other half jointly to Demis Hassabis and John M. Jumper "for protein structure pr...
I’m curious about how strong TCR signals (low epitope load-high affinity/high epitope load-mid affinity) relate to T cell fate. Anyone have new publications (or opinions!!) to share on that topic? #Immunosky
More than 30 follows in 24h for this wallflower is kinda intimidating. What is with the sudden influx? Did a new door just open?
Anyone in my orbit read fantasy? I am reaching the end of Robin Hobb’s Realm of Elderlings and will desperately miss her characters. Any rebound reading recommendations?
📣 New publication! Boosting of HSV-2 specific T cells observed in the skin following therapeutic herpes vaccination. Shout out for Dr Emily Ford for driving this over the finish line. insight.jci.org/articles/vie...
Our new publication led by Dr Tara Reid uncovers proteins in Treponema pallium that are targets of CD4 T cells. Useful information towards improved prevention and treatment of syphilis. academic.oup.com/jid/advance-...
Little is known about the targets of effector T cells during human syphilis. Herein we show that Treponema pallidum infection elicits antigen-specific CD4+
'First, our analysis of vertebrate genomes, including the hagfish, now establishes a robust and accurate history of WGD events in early vertebrates, corroborating the idea that cyclostomes diverged from gnathostomes after the 1R but before the 2R event' www.nature.com/articles/s41...
Analysis of a newly sequenced genome of the inshore hagfish, Eptatretus burgeri, together with genomes of lampreys and jawed vertebrates, provides insights into whole-genome duplication events and the...
So wonderful to see the availability of genome sequences from more species filling in missing pieces of the puzzle in the evolution of the CD4 gene family. Extra genes and other oddballs; fish immune systems are full of intrigue. #FishImmFanGirlwww.frontiersin.org/articles/10....
CD4 and LAG-3 are related molecules that are receptors for MHC class II molecules. Their major functional differences are situated in their cytoplasmic tails, in which CD4 has an activation motif and ...
Go Dawgs!