We're still pretty excited about all the new insights gained from this scRNAseq study of Enterococcus faecalis wound infection, now up on @elife.bsky.social@gthibault.bsky.socialdoi.org/10.7554/eLif...
Very cool paper by Daria van Tyne, Breck Duerkop and others 'Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia' journals.asm.org/doi/10.1128/...
Phage therapy is an emerging therapeutic approach for treating bacterial infections that do not respond to traditional antibiotics. The addition of phage therapy to systemic antibiotics to treat a pat...
PhD student opening! We are collaborating with the team of David Johnson @EawagResearch to understand E. faecalis polymicrobial community assembly, interactions, and consequences for AMR and infection. Details of the position and how to apply can be found here: tinyurl.com/ywa52a6a.
2023 was a (mostly) good year to us. I am so grateful to work with such a smart, inspring, kind, and fun group of people. I can't wait to see what 2024 has in store for this team!
And last preprint of 2023! Postdoc Ronni da Silva's latest in a project aimed at repurposing drugs to reprogram macrophages to treat ESKAPE pathogen infections. Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria www.biorxiv.org/content/10.1...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Last paper of 2023 out in mBio, wherein we're learning more about how E. faecalis infects and persists within wounds and other infection sites. Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections. journals.asm.org/doi/10.1128/...
And now the Version of Record of our PrgB paper is out in @elife.bsky.socialdoi.org/10.7554/eLif...
The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.
The latest preprint from the lab is up. Here we asked how the cell responds when pilus biogenesis goes off the rails in E. faecalis. 😱 Come for the chaperone/protease action, stay for the WEIRD morphologies and two component system induction. 👇
The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis https://www.biorxiv.org/content/10.1101/2023.11.20.567783v1
Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faeca