So, welcome to your new genomic era understanding of an old disease threat: S. Panama! It was an honour co-supervising @1caiseypulford’s PhD work with @jay_salsa and working with the tireless @weill_xavier who absolutely made this work happen 7/8
The ‘invasiveness index’ (thanks @nwheeler443) of S. Panama was elevated relative to other broad host-range Salmonella serovars and highest in the European- AMR- associated Clade 2, suggesting this might pose the greatest public health threat 6/8
Predicted AMR was carried by gene cassettes against some old favourites (streptomycin, ampicillin, chloramphenicol, trimpethoprim, sulfisoxazole, and tetracycline) and one XDR isolate with further fluoroquinolone, polymyxin, and 3rd generation cephalosporin resistance 5/8
There were low rates (14.5% of isolates) of AMR predicted in S. Panama and AMR was typically found in the clades associated with Europe and Asia 4/8
The usual tricks (phylogeny and BAPS clustering) revealed four geographically associated clades, including some further island-associated substructure in the Caribbean 3/8
Together with an amazing set of public health collaborators we assembled a diverse set of 836 S. Panama genomes from different disease presentations and global regions spanning nearly 100 years 2/8
Did you know Salmonella Panama is an important cause of diarrhoeal and iNTS disease globally? Our genomics work driven by @1caiseypulford & @BlancaPerSep characterises diversity, AMR, & invasiveness to bring new insights into this pathogen bit.ly/3I2Uo3B1/8 1/8
Only one week left for abstract submission to #AMR2024bit.ly/3YtV1dG
Working on antimicrobial resistance and AI/ML, wastewater monitoring, use of pathogen genomics in hospital/clinical settings, surveillance, among other topics? Submit your abstract and come present at 'AMR: Genomes, Big Data and Emerging Technologies' Deadline Jan 16 See tinyurl.com/2p8d7y8a