Definitely depends on the game, but some are very easy. The Wildsea, for example, just needs some creativity and a willingness to embrace the Weird. So long as you can describe what you're doing/planning, you don't need to know the mechanics. That's my job as GM to turn it into mechanics.

There's a furry dating sim I was looking into for streaming and I immediately noped out once it mentioned table top and DnD terminology 😅 I'm oblivious to it all