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Mark Ungrin
@mark-ungrin.bsky.social
Parent. Interdisciplinary biomedical researcher. Hardline scientist. PhD (Medical Biophysics, Cellular & Molecular Biology). Faculty. New platforms and real-world impact, emphasis on scientific rigour, reproducibility and efficiency. Diverse interests.
201 followers67 following32 posts
MUmark-ungrin.bsky.social

Just updated our preprint assessing the 2022 study that claimed medical masks to be noninferior to N95s for COVID. In addition to issues identified previously, a closer examination of the data revealed unexpected patterns unlikely to occur in nature: osf.io/preprints/me...

Abstract
Background
A previously published study is cited as evidence that medical masks (MM) are noninferior to N95 respirators (N95) in the prevention of COVID infections. As COVID is transmitted via infectious aerosols generated during coughing as well as routine activities such as breathing and speaking, and N95s (in contrast to MM) are designed, validated and specified in national standards to provide protection against such hazards, we re-analysed the published data to resolve this unexpected result.
Methods
Study data was extracted from the publication, and analyses pre-specified in the original study protocol but omitted from the publication were carried out. Anomalies identified in the process were subject to additional analyses for statistical significance.
Results
Prespecified analyses reverse the reported outcome, which is the product of multiple alterations to the trial that were not introduced into the registry until after publication. Methodological shortcomings include
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MUmark-ungrin.bsky.social

So apropos of absolutely nothing I asked Perplexity AI what the worst medical error of all time was, and how it relates to the WHO's failure to recognize airborne transmission of COVID. Even the machines know what's up. Link to results (with references): www.perplexity.ai/search/What-...

What was the most harmful medical error of all time?
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Answer
The most harmful medical error of all time was the Tuskegee syphilis study, a clinical study conducted by the U.S. Public Health Service from 1932 to 1972 that involved deliberately withholding treatment from African American men with syphilis without their knowledge or consent
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The study recruited 399 poor African American men in Alabama who had syphilis, but researchers did not inform the participants of their diagnosis or provide them with treatment, even after penicillin became the standard cure for syphilis in 1947
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. Instead, the researchers watched the disease progress in the men, who suffered severe complications and death as a result. By the end of the study in 1972, 28 of the original participants had died directly from syphilis, 100 died from complications related to the disease, 40 of the participants' spouses had contracted syphilis, and 19
How does that relate to the WHO's failure to recognize airborne transmission of COVID?
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Answer
The failure of the World Health Organization (WHO) to promptly recognize the airborne transmission of COVID-19 is related to the Tuskegee syphilis study in several important ways:
Both cases involved a failure by public health authorities to acknowledge and act on clear scientific evidence, prioritizing convenience and political considerations over the health and safety of vulnerable populations
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In the Tuskegee study, researchers deliberately withheld treatment from African American men with syphilis, causing immense harm and suffering. Similarly, the WHO's reluctance to recognize airborne transmission of COVID-19 led to inadequate protective measures, exposing healthcare workers and the public to increased risk
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The Tuskegee study eroded trust in the medical establishment, particularly among African Americans. The WHO's d
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Reposted by Mark Ungrin
DFdfisman.bsky.social

The whole airborne thing for sars-2 has been pretty depressing, and WHO still seems to be spending ink, capital, and resources to allow a small group of old men to attain plausible deniability. That said:

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Reposted by Mark Ungrin
BGkenwhite.bsky.social

It would be wrong to see this as just a prudish or Victorian or even sincerely religious attitude about sex. It’s about control. It’s about the authority of the state intruding into more and more parts of life, and about making more and more people complicit in the abuse of power. /1

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MUmark-ungrin.bsky.social

They don't even work for doctors. Just stepping stones for a few political types, on their way to bigger and better things - while the actual health care workers they sold out get long COVID and burn out trying to hold healthcare together. Integrity requires this: www.bma.org.uk/advice-and-s...

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MUmark-ungrin.bsky.social

IMO the biggest problem that medicine faces is that it consistently picks the worst human beings in the profession for leadership roles. The second biggest is culture, and the collusion that enables the harm those leaders do. Cheers to those fighting back! www.tandfonline.com/doi/full/10....

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MUmark-ungrin.bsky.social

Like a hammer, RCTs can be effective tools under the right circumstances. But not everything is a nail. 🧵

A screenshot of the introductory material to a paper describing a randomized controlled trial of parachutes from an elevation of 0.6m. https://www.bmj.com/content/363/bmj.k5094
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MUmark-ungrin.bsky.social

So all a trial that finds otherwise at the community level can tell us is that the team running the trial did not choose and effectively communicate appropriate protocols for their use. There is no magical property of RCTs that can change that fact.

A man wearing a medical mask as a blindfold.
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MUmark-ungrin.bsky.social

With adequate training, workers in a broad range of industries know from experience that they are quite capable of wearing their PPE consistently. And a well-fitting N95 can stop transmission - at this point all but the most fanatical airborne-deniers have accepted that fact.

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Mark Ungrin
@mark-ungrin.bsky.social
Parent. Interdisciplinary biomedical researcher. Hardline scientist. PhD (Medical Biophysics, Cellular & Molecular Biology). Faculty. New platforms and real-world impact, emphasis on scientific rigour, reproducibility and efficiency. Diverse interests.
201 followers67 following32 posts