MJ
Matthew J Shepherd
@matthewjshepherd.bsky.social
Postdoc at the University of Manchester, with Prof. Mike Brockhurst. Understanding and predicting the evolution of antimicrobial resistance in clinical Pseudomonas 🔬🦠
267 followers260 following26 posts
We summarise evidence for four prevailing mechanisms of AMR emergence within-patient: i) Spontaneous mutation, ii) Horizontal transfer (de novo mechanisms), iii) Selection of existing resistance, and iv) immigration of resistant lineages from elsewhere (ecological mechanisms) 2/7
🥳🥳🥳🥳 brilliant, congratulations
We also discuss how the prevailing mechanism likely varies between infecting organism, infection site within the body, infection duration and bacterial lifestyle 3/7
MJ
Matthew J Shepherd
@matthewjshepherd.bsky.social
Postdoc at the University of Manchester, with Prof. Mike Brockhurst. Understanding and predicting the evolution of antimicrobial resistance in clinical Pseudomonas 🔬🦠
267 followers260 following26 posts