🔥 We have an updated preprint for you, complete with Nano-tRNAseq(!!!), mass spec analysis of tRNA mods, and a more complete mechanism of 5-FC resistance. We got some great help with this edition from the Gsaller & Kaiser labs. Hope you like it! biorxiv.org/content/10.1...

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus.

Increasing antifungal drug resistance is a major concern associated with human fungal pathogens like Aspergillus fumigatus . Genetic mutation and epimutation mechanisms clearly drive resistance, yet t...