But infections are less likely to be severe in those with prior infections/vaccinations! JN.1 may more easily infect (evade nAbs) in prior infected/vaccinated but will then encounter a stronger memory-cell response preventing a severe infection. 3/

This of course was the story with omicron's emergence during delta circulation: Omicron cases were observed to be *much* milder, but they were much more likely to be "breakthrough" infections. Actual intrinsic differences in severity smaller. 4/