Depends on the board and what I have in hand, but I try to build up a lane with Squirrel Girl, a 2-cost, and/or Debrii. From there, I usually know if I want to buff my side up for a wider spread or need to debuff/go tall with Ajax/Mystique. Red Guardian could possibly be Rogue/other tech.

And forgot to mention, Cassandra Nova was probably my last cut. I originally tried Hood but liked tech better.