Very happy to see the “optoscillator” - a synthetic optogenetic oscillator - published! By applying light pulses on growing E. coli colonies and analysing the ring patterns, we observed synchronisation, (subharmonic) resonance, period doubling and chaos! www.nature.com/articles/s41...
Oscillations are a recurrent phenomenon in biological systems across scales, but deciphering their fundamental principles is very challenging. Here the authors construct a synthetic oscillator in bact...
Our article on microbial interactions is out! We discuss what are microbial interactions, what are they useful for, and how to quantify them. For more, see lead author @nittaym.bsky.socialx.com/NittayMeroz/...shorturl.at/ONiNS
Happy to share our latest manuscript we we study evolutionary rescue in a bacterial mutualism: Reversion to metabolic autonomy underpins evolutionary rescue of a bacterial obligate mutualism shorturl.at/tFNTw
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Brilliant paper. A great example of how principles of quantitative physiology can inform our understanding of microbial evolution. "Proteome partitioning constraints in long-term laboratory evolution" www.nature.com/articles/s41...
Sharing the preprint for my first foray into experimental evolution: adaptation of Pseudomonas aeruginosa to repeated invasion into a commensal competitor 🦠🧬 www.biorxiv.org/content/10.1...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Almost a decade after proposing this experiment in a grant application, we have a preprint! A huge experiment by Philippe Piccardi with many helping hands to generate and analyze the data especially genomic & transcriptomic analysis by Eric Ulrich! www.biorxiv.org/content/10.1...
We have a new preprint testing our previous evolutionary forecasts in two Pseudomonas species. Some successes & some surprises. Work mainly by Jennifer Pentz, with Aparna Biswas and Bassel Alsaed. www.biorxiv.org/content/10.1...
New collaborative work from our lab on the transmission of AMR in a community context. www.biorxiv.org/content/10.1... We find that Gram positive bacteria, particularly enterocci, increase the conjugation efficiency of uropathogenic E.coli.
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
1/5 Can random sequences encode meaningful functions and allow de novo gene birth? To explore this, Michael Laub and I screened 100 million random genes, without sequence similarity to natural genes, for their ability to rescue growth arrest of E. coli cells producing the ribonuclease toxin MazF.
We are really curious to hear what people think, so if you have some thoughts, please share with us! 10/10