Takashi Satoh's group showed us how IL-10 may induce ACE2 expression in AMs to promote COVID-19 severity ..with CiDRE+ AMs being more sensitive to IL-10. [9/n] www.cell.com/immunity/ful...
Elucidating the mechanism underlying COVID-19 severity is essential for individualized therapy. Mitsui et al. demonstrate that IL-10 induces ACE2 expression in alveolar macrophages and promotes COVID-...
Jie Sun's group reported that bcat::HIF1a signaling drives the AM proliferation and stemness vs inflammatory activity during respiratory infections in this elegant study [10/n] www.cell.com/immunity/ful...
Zhu et al. examine the relationship between proliferative and inflammatory properties of tissue macrophages by defining the impact of the Wnt-β-catenin pathway, a regulator of self-renewal, in alveola...