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Pete Schmidt
@pnschmidt.bsky.social
Scientist; Chief Scientific Officer @ Rho; discoverer of scary links between COVID-19 and neurodegeneration.
42 followers62 following59 posts
PSpnschmidt.bsky.social

Many of the “split the baby” ruling scenarios contemplate some degree of immunity for presidents within their official sphere, however the implications would then have to trickle down to make sense, with immunity for following an unlawful order implied, no?

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PSpnschmidt.bsky.social

What is your position on Van Gogh? I was embarrassed when I first heard a Dutch person say the name, but then I decided to relax and not worry about it. Verbalization is for communication, so if “the right way” is unintelligible to your audience, it is wrong.

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PSpnschmidt.bsky.social

There seems to be a Dunning-Kruger aspect to SBF: smart enough that people convinced him that he was smarter. But to not understand the game theory that underlay his strategy means he wasn't all that good at math. The game theory he describes in interviews shows his thin grasp of strategy. (5/end)

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PSpnschmidt.bsky.social

SBF/FTX ran this way - understanding odds x return = EV, but not that a bet with a 0% chance to win infinity dollars can have a positive EV but be stupid to play. FTX made a bunch of massive upside vs implode bets. They won massive upside several times. But they imploded once. That's enough. (4)

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PSpnschmidt.bsky.social

Play 25 games with a 51% chance of +1 & 49% chance of -1. Net expected value (EV) is 1.5, or 25 times 0.02 net positive. Now run 25 games with a 51% chance of 2x return and 49% chance of ending the game. EV = 1.64, because 2^25 is a big number. But the odds of a non-zero return are 1 in 2x10^7. (3)

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PSpnschmidt.bsky.social

Why is this bad math? After two such wagers, the odds of destroying humanity would be 74%. SBF’s analysis ignored that his model had negative but no positive game-ending outcomes. The right framework for such a thought experiment is not “double or nothing,” it’s “double or half.” (2)

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PSpnschmidt.bsky.social

Call your congressional offices (1 rep + 2 senators) and tell them that you want NIAID to continue to advance our knowledge of infectious disease (after a pandemic!) and immunology. Many recent breakthroughs across medicine have come from new insight into antibodies and immune system cells.

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PSpnschmidt.bsky.social

Agree! However, it appears that Wordlebot does consistently use this 2nd word in the same situation.

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PSpnschmidt.bsky.social

The earlier experience doesn’t mean success is impossible in these new trials, but we do know what to expect and what outcomes would represent meaningful progress. For example, clinical benefit in open-label studies was achieved in earlier trials, the challenges come with blinding.

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PSpnschmidt.bsky.social

I’m in Durham 9-5 on weekdays… or maybe 8-6. Sometimes 8-7.

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Profile banner
PS
Pete Schmidt
@pnschmidt.bsky.social
Scientist; Chief Scientific Officer @ Rho; discoverer of scary links between COVID-19 and neurodegeneration.
42 followers62 following59 posts