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Ralf Wittenbrink
@ralfwittenbrink.bsky.social
Es gibt immer noch eine große Lücke zwischen dem, was die Öffentlichkeit über COVID-19 weiß, und dem, was sie wissen sollte. Deshalb hier Infos über COVID-19.
7.7k followers407 following3.6k posts
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einer Dysregulation wichtiger kardialer Transkriptionsfaktoren wie SIX1, MEF2C und TBX5 verbunden. Die erhöhte Infektiosität von #Omicron BA.2 wird auf seine Fähigkeit zurückgeführt, über Endozytose zu infizieren, unabhängig von TMPRSS2, das in CMs fehlt. Die Studie unterstreicht

Delta, Omicron BA.1, and BA.2 induce distinct expression changes in hiPSC-CMs. Human iPSC-CMs were infected with Delta (D), Omicron BA.1 (O-BA.1) or BA.2 (O-BA.2) at MOI of 1. The expression of A RdRp, B genes important for cardiac function was measured by RT-qPCR, normalised to B2M expression. Data are mean ± SEM, n = 4 biological replicates. Statistical analysis was performed using one-way ANOVA followed by Tukey’s multiple comparisons test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Differentially expressed genes in BA.2 group were examined by Ingenuity pathway analysis to predict upstream regulators. C Activation z-score indicates the activation (+) and inhibition (−) of the regulator, significance is indicated by the p-value of overlap. Expression is shown as log of fold change (FC). Regulators with consistent direction of activation score and expression change are shown in bold; D predicted downstream genes of selected regulators and E diagram of regulatory network, …
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die Notwendigkeit weiterer Untersuchungen, um die Pathogenese von Herzkomplikationen zu definieren, die durch verschiedene #SARSCoV2cellandbioscience.biomedcentral.com/articles/10....#OmicronIsNotMild#OmikronIstNichtMild#HeartDisease#LongCovid#COVID19#OrganDamage

SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo - Cell & Bioscience
SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo - Cell & Bioscience

Background COVID-19 can cause cardiac complications and the latter are associated with poor prognosis and increased mortality. SARS-CoV-2 variants differ in their infectivity and pathogenicity, but ho...

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Ralf Wittenbrink
@ralfwittenbrink.bsky.social
Es gibt immer noch eine große Lücke zwischen dem, was die Öffentlichkeit über COVID-19 weiß, und dem, was sie wissen sollte. Deshalb hier Infos über COVID-19.
7.7k followers407 following3.6k posts
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