If you’re not sold on scRNAseq, this is my favorite analogy on why measuring average properties of diverse samples can be misleading. What are the average properties of an animal at a zoo, and what would that actually tell you about that zoo? Bulk transcription of blood is kinda like this.

This was part of a long-standing collaboration w clinical colleague Mike Filbin at MGH, led by the incredible duo of Alyssa DuBois (RA extraordinaire) & Pierre Ankomah (ID doc & postdoc / junior mentored faculty) in my lab, and funded largely by an R21 from NIGMS.