shout out to @jferrare.bsky.social !!!!!
From Ben Good: competition btwn linked mutations can..enhance selection for modifiers that increase benefits of future mutations, even when they impose a strong direct cost on fitness. However..modest direct benefits can..drive evolutionary dead ends to fixation. www.nature.com/articles/s41...
Evolvability modifier mutations alter the rates and benefits of future mutations, but it is difficult to predict when they will be favoured by natural selection. A mathematical framework shows that co...
From Ben Good: competition btwn linked mutations can..enhance selection for modifiers that increase benefits of future mutations, even when they impose a strong direct cost on fitness. However..modest direct benefits can..drive evolutionary dead ends to fixation. www.nature.com/articles/s41...
Evolvability modifier mutations alter the rates and benefits of future mutations, but it is difficult to predict when they will be favoured by natural selection. A mathematical framework shows that co...
Experimental capture of genomic islands defines a widespread class of genetic element capable of non-autonomous transfer www.biorxiv.org/content/10.1101/2024.08.29.610337v1
Bacteria acquire new genes by horizontal gene transfer (HGT). Acquisition is typically mediated by m
I wrote a little perspective piece www.cell.com/cell/fulltex...www.sciencedirect.com/science/arti...@asanchezlab.bsky.social and colleagues.
Microbial communities perform many important functions, such as carbon sequestration, decomposition, pathogen resistance, etc., but quantitatively predicting functions of new communities remains a maj...
These ingestible pills are awesome—just a fantastic tool to see what's actually going on inside the gut elifesciences.org/articles/85567
Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.
Paradoxically, preventing infection with high ABX can make patients susceptible to subsequent infections like C diff as gut flora get wiped out. Developing ABX that act in concert with the commensal microbiome to resist pathogens is a triumph www.nature.com/articles/s41...
Lolamicin, a novel antibiotic developed from a pyridinepyrazole precursor, exhibits potent activity against a broad range of Gram-negative multidrug-resistant clinical isolates, and good efficacy...
Scientists have managed to generate a full genetic sequence of #H5N1#birdfluwww.statnews.com/2024/05/21/b...
Store-bought milk could provide a work-around, University of Washington and Fred Hutchinson researchers suggested, similar to wastewater surveillance.
Firmicutes appear to harbor host-specificity genes that allow them to bind to particular physical niches in the host gut I got to play a very minor role in this amazing work, and I'm so excited to see it out www.biorxiv.org/content/10.1...
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