THIS IS HUGE! Researchers at the University of Pennsylvania have developed a vaccine against the bacterium Clostridioides difficile (C.diff), that in preclinical studies, protected against succumbing from infection AND prevented recurring cases. Let’s talk about that! 🧪🧵⬇️
AMAZING. Selfishly, my first thought is wondering if (way down the road) this might help IBS sufferers, since the current understanding is that some people develop IBS after food poisoning. 🤞
Is this one of those "in mice" things that might not pan out in humans, or is there reason to believe it's one of the exceptions?
Very exciting news! I hope the clinical trials prove out :)
*googles* 450,000 cases/year in the US, causing 30,000 deaths (2011 numbers, rounded) YEAH I'm not playing with that percentage, I look forwards to that shot
As someone who studied in a lab that worked on outer membrane constituents in pathogenic bacteria, this is incredible and fascinating! I have told people that mRNA vaccines would change the world and we are just starting this journey.
This IS huge! My sister in law had a C Diff infection early this year, and it was terrible.
Genuinely massive news. Huge congrats to the team at U. Penn.
So far in mice, but in principle there's no reason it shouldn't work in humans. Really good news!
Isn't this the infection that is sometimes only cured with a whole-colon fecal flush and transplant from a healthy donor?