Good/Quick Read "Distributions of conformations are the future of structural biology" Actually they are the contemporary of #structbio@sjorsscheres.bsky.social released ReLION 1.13 way back in idk 2014, model free ab initio refinement and 3D classification were part of the standard protocol
Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are ...
"dynamic nature of proteins is widely accepted, the fact that structural heterogeneity manifests regularly in experimental structures — those in the Protein Data Bank (PDB) today — appears underappreciated" I think this is largely true. For non-structural biologists its just not the first thought.
It never ceases to amaze me how often someone says “the dynamics of proteins are important” as if they are the first person to realize that. Also AF2 can sample multiple conformations so the main premise in this article is wrong.