Hugely depends on the game, by my favourites are: FNV: stealth sniper, cause Boones my boy, or medicine +luck because I'm still chasing that Skids high, and FNV is the only game where being a doctor feels like it gives you enough RP benefit fir doing so. Always wacky wasteland, always survival.

Fo4 very different line, because of how good power armour feels. Just make me as tanky as I can be as soon as I can. Crank into up to level science, then choose a random weapon type. I don't really like conversations only working off cha, so I dont really engage with it