Besides the examples where it's sometimes possible to predict from single sequence. There have been other examples where it was not possible. If it is memorization, why would AF memorize one example and not another? 🤔 twitter.com/GMondaSilva/... (7/8)

But back to our paper... we explore this question in the SI, and actually take advantage of the fact that single sequence is sometimes enough to design a new protein where a few point mutations switch to the alternative conformation. 🤓 (8/8) www.nature.com/articles/s41...