Another MS Society #citytoshore in the bag! It was a good cycle ride yesterday - but a bit tougher than usual given suboptimal weather

An amazing effort fron many, inclueing Julius Juodakis, Bo jacobsson, @bfeenstra.bsky.social@struangrant.bsky.social@jonathanbradfield.bsky.social Karin Ytterberg, Abe LaBella, Stefan Johansson, Marc Vaudel, Xiaoping Wu, and many more! Thanks to all involved and the participants!

A little bit late to the party, but our project on the genetics of neonatal jaundice has been finally published 👶 www.nature.com/articles/s41... It's a neat story and a rollercoster of unexpected findings 🤓🤓 How do the genetics of neonatal jaundice differentiate from those of adult bilirubin?

Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism - Nature Communications

The underlying causes of neonatal jaundice are not well understood. Here, the authors identify genetic variants associated with neonatal jaundice, including a variant in the gene UGT1A, finding a dist...

PREPRINT: Co-mentored with Laura Almasy, & formerly Casey Brown, @cambupenn.bsky.socialwww.biorxiv.org/content/10.1...

Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver

Non-coding variants discovered by genome-wide association studies (GWAS) are enriched in regulatory elements harboring transcription factor (TF) binding motifs, strongly suggesting a connection betwee...

From the @cambupenn.bsky.social#STARProtocolswww.sciencedirect.com/science/arti...

PREPRINT: Our Children's Hospital of Philadelphia Research Institute team, including Andrew Wells, delighted to contribute to a large-scale multi-omic analysis of pancreatic ductal adenocarcinoma, led by Jun Zhong and Laufey Amundadottir www.medrxiv.org/content/10.1...

Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma

medRxiv - The Preprint Server for Health Sciences

Congratulations to Dr Elizabeth Burton! PhD awarded today with @cambupenn.bsky.social. Good luck with next steps at The Broad Institute

Just out in @elife.bsky.socialelifesciences.org/articles/96852

Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.

Exciting work from Adrian Vella's team at the Mayo Clinic implicating a role for the #TCF7L2diabetesjournals.org/diabetes/art...

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

The T allele at rs7903146 in TCF7L2 increases the rate of conversion from prediabetes to type 2 diabetes. This has been associated with impaired β-cell fun

I am recruiting a PhD student, co-supervised with George Davey-Smith, Gareth Hawkes and Laura Corbin to study trait residualized for known genetic influences, please Apply! gw4biomed.ac.uk/shining-a-li...