Absolutely captivating article from @fraserlab.bsky.socialwww.cell.com/cell/fulltex...

Radha follows up her work with a publication in Langmuir. She used NMR hydrogen exchange and methylation mass spec to probe the structure of a small protein binding to a polystyrene nanoparticle. She finds evidence consistent with the adsorbotope model. doi.org/10.1021/acs....

#MassspecSOS

Here’s a good one for TeamMassSpec (I hope!)- I’m working on a small project which involves enrichment and MRM of circulating neuropeptides (from blood plasma). Most are hydrophilic peptides (< 3 kDa), 1 is amphipathic (~60 kDa).

Anyone with experience of converting Waters .raw files into mzML (or something) that can be searched with Fragpipe and other software? MS Convert settings that work would be very helpful. #MassSOS

I have struggled with this since we have gotten our Synapt XS. Add ion-mobility ontop of it and...yah. This sometimes works for me, but I have not tried it with FragPipe after. github.com/AnP311/Water...

Pls reskeet: We're accepting PhD apps to Syracuse University Biology! (Priority deadline of 1/4/24) Join a vibrant department: we are also recruiting three new faculty in epigenetics and neuroscience! Labs actively recruiting grad students are here: artsandsciences.syracuse.edu/biology/grad...

Ohhhh, that would be great! Will send email later this evening so you can get to it when you have the time....

I now have some lab listening for tomorrow. Hee hee hee.

So agree. It was like sending up the batsignal! This is why I stand by my comments on the mass spec community being amazing people who don't eat their young (or noobies).