BLUE
Profile banner
JV
Jim Van Deventer
@vandeventerjim.bsky.social
Chemical and Biological Engineering, Tufts University. Antibody engineering with expanded genetic codes, enhancing genetic code expansion in yeast, and more.
81 followers707 following18 posts
JVvandeventerjim.bsky.social

Most striking findings: isolation of aminoacyl-tRNA synthetase variants that support efficient noncanonical amino acid incorporation even at extremely low concentrations in the media. This is extremely rare for evolved aminoacyl-tRNA synthetases (across literally hundreds of studies!). (2/2)

0
JVvandeventerjim.bsky.social

Chang Liu's lab (UC Irvine) created a system for rapidly evolving aminoacyl-tRNA synthetases for genetic code expansion. Yuichi Furuhata + Gordon Rix led exptl effort. The work also utilized some of my lab's reporter systems during screening. (1/2) Preprint: www.biorxiv.org/content/10.1...

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation
Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation

Genetic code expansion (GCE) has become a critical tool in biology by enabling the site-specific incorporation of non-canonical amino acids (ncAAs) into proteins. Central to GCE is the development of ...

1
Reposted by Jim Van Deventer
RSrichardsever.bsky.social

"hard to say if that result is an honest failure of a worthwhile idea or the entire effort has been built on data that simply aren't real" www.science.org/content/blog...

Fraud, So Much Fraud
Fraud, So Much Fraud

1
JVvandeventerjim.bsky.social

Not as great news: administrator asking why the value of the award is the same as the cost of the instrument we are purchasing. Response I wanted to give, minus expletives: "dude, how do you not know that this is a thing?!? We requested the quoted price of the instrument and were awarded it. Duh!"

0
JVvandeventerjim.bsky.social

Great news: the Van Deventer Lab has received supplemental funding to further advance chemically expanded antibody engineering and its applications! We are purchasing a new analytical flow cytometer. Thank you, NIH!

Snapshot of Notice of Award for flow cytometry instrumentation.
0
Reposted by Jim Van Deventer
KGkarlgalle.bsky.social

I am overjoyed to announce that I have secured tenure and promotion! Many people made this possible. My research group learned to thrive during the pandemic, my family was relentlessly supportive, and many others propelled me onward…there is a lot to be thankful for!

Photos of the Van Deventer Lab
1
Profile banner
JV
Jim Van Deventer
@vandeventerjim.bsky.social
Chemical and Biological Engineering, Tufts University. Antibody engineering with expanded genetic codes, enhancing genetic code expansion in yeast, and more.
81 followers707 following18 posts