New preprint from the lab describing how most poxviruses, including avipoxviruses, antagonise DNA-PK to block cGAS/STING-dependent interferon production during infection. www.biorxiv.org/content/10.1...

Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism

The sensing of viral nucleic acid by pattern recognition receptors (PRRs) is essential for initiation of a type-I interferon response against infection. Intracellular DNA sensing PRRs are responsible ...

Given the PHEIC declaration, there has been a lot of interest in setting up Mpox surveillance programs. To help labs get up and running with molecular and sequencing-based assays, we have created a framework document that we hope will be helpful to the community. andersen-lab.com/secrets/prot...

Mpox surveillance - Andersen Lab

medicalxpress.com/news/2024-09...

Mpox vaccines administered in Rwanda, first in Africa

Mpox vaccines have been administered in Africa for the first time, with several hundred high-risk individuals vaccinated in Rwanda, the African Union's disease control center said Thursday.

Can you solve these three vaccine puzzles? New post on the counterintuitive features of vaccine rollouts during dynamic epidemics: blog.kucharski.io?three-vaccin...

Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography www.cell.com/cell/fulltex...

Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography

In-cell cryo-electron tomography has uncovered the Ebola virus nucleocapsid assembly and condensation processes. The resulting 9 Å map of fully assembled nucleocapsids within the viral replication fac...

The UK has bought 150,000 more doses of Bavarian Nordic's #mpoxwww.gov.uk/government/n...

UK secures more vaccines to help boost resilience against mpox

Additional vaccines will help ensure the UK can protect those that may be at high risk from mpox

'The World Health Organization has given its authorization to a first vaccine to protect against #mpoxwww.nytimes.com/2024/09/13/h...

W.H.O. Authorizes Mpox Vaccine, Clearing Way for Use in Africa

The decision is a crucial step in getting shots to the Democratic Republic of Congo, the center of the outbreak.

Mpox is a public health emergency — what happens now? Africa CDC has declared its first Public Health Emergency of Continental Security. www.nature.com/articles/d41...

Mpox is a public health emergency — what happens now?

Africa CDC has declared its first Public Health Emergency of Continental Security. Africa CDC has declared its first Public Health Emergency of Continental Security.

AIRE is still full of surprises, such an interesting protein

RRrodrahimi.bsky.socialMar 16, 2024 12:59am

Okay, this is really cool "We propose a model in which Z-DNA anchors the AIRE-mediated transcriptional program by enhancing double-stranded break generation and promoter poising." #Immunology 🧪

AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization - Nature

Z-DNA anchors the AIRE-mediated transcriptional program by enhancing the generation of double-stranded breaks and promoter poising.

🧪 Long overdue www.science.org/content/arti...