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SSscibot.bsky.social

SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner Emerging Microbes & Infections - Zhou, 2022 Temp link here: sci-hub.se/10.1080/22221751.2022.2059403

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TCcyrilpedia.bsky.social

There is absolutely no data showing a resulting immune deficiency in vivo (or even in vitro) in the article, Fig 1-8 deal with models of binding of a mAb, a nanobody, S & N ptns to CD147. That's it, & not even dragging Karl Popper into this (they do, in the discussion) supports any other conclusion

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TCcyrilpedia.bsky.social

It's a very unfortunate title (even if the text uses the indefinite article "an", I wish they had not used upper case). To be clear, all data in this article is modelling putative interactions between N-Protein and CD147.

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TMthailandmedical.bsky.social

Thailand Medical Study Shows That Certain Thai Traditional Medicines Reduce CD147 Levels In Lung Cells. Possible Use In Cancers And COVID-19! www.thailandmedical.news/news/thailan...

Thailand Medical Study Shows That Certain Thai Traditional Medicines Reduce CD147 Levels In Lung Cells. Possible Use In Cancers And COVID-19! - Thailand Medical News
Thailand Medical Study Shows That Certain Thai Traditional Medicines Reduce CD147 Levels In Lung Cells. Possible Use In Cancers And COVID-19! - Thailand Medical News

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What ever could be going wrong here? HIF‐1α driving problems, in an autoimmune related inflammatory disorder? pubmed.ncbi.nlm.nih.gov/34048873/

The results showed that hypoxia for 6 h on the 17th gestation day is most likely to lead to autistic behavior in offspring rats, including social deficits, repetitive behaviors, and impaired learning and memory. The mRNA expression level of TNF-α also increased in hypoxia-induced autism group and valproic acid (VPA) group.
_ @ultimape · Jun 24, 2020
Replying to  @ultimape @CTZN5 and @__ice9
Lets see.

CD147 triggers weird angiogenesis problems in Rehumatoid Arthritis. "CD147 induces up‐regulation of VEGF and HIF‐1α in RA FLS"
https://onlinelibrary.wiley.com/doi/full/10.1002/art.34341

Suspected that ACE2 acts on VEGF-A possibly increasing "vascular leakiness and permeability" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3604987
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