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Environmental cues shape RTM development and tissue adaptation.

Distribution of long-lived RTMs across tissues and organs.

Tcastltrastondrs.bsky.socialDec 1, 2023 5:36am

MedSky🧪#IDSky #Cellimmunity #Cellbiology #Monocytes #COVID19 prognosis.

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#MedSky🧪#cancerresearch #CellImmunity #lymphnodes #chronicinflammation.

The figure illustrates the different types of tertiary lymphoid structures (TLS) found in tumors. TLS are defined as organized immune aggregates with distinct T and B cell zones, surrounded by peripheral node addressin (PNAd)-expressing high endothelial venules.
(A) Immature or early TLS contain mature dendritic cell lysosomal associated membrane glycoprotein (DC-LAMP)+ dendritic cells (DCs) in the T cell zone.
(B) Within mature TLS, primary follicle-like TLS have in addition T follicular helper (Tfh) cells and CD21+ follicular dendritic cells (FDCs) network allowing T cell immunity activation and low-affinity antibody production.
(C) Secondary follicle-like TLS are characterized by the presence of a germinal center (GC) with B cell lymphoma 6 (BCL6) positive GC B cells, CD21+CD23+ FDC allowing the production of memory B cells and high-affinity antibody secreting plasma cells. Boxes indicate their potential impact on cancer control and on clinical outcome. TCF1, T cell factor 1. Create

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MedSky🧪#Immunology #Cellimmunity #leukocytes id recruited within short time frames because immunological threats arise at unpredictable sites in the body. twitter.com/ScienceMagaz...

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MedSky #Cellimmunity T cell immunity of vaccinated individuals against Omicron sub~variants remains largely intact due to the nature of polymorphic cell-mediated immune responses, may continue to contribute to prevention/limitation of severe #COVID19 manifestation.